Antimicrobial Flavonoid from Hibiscus rosa-sinensis Linn.

Antimicrobial Flavonoid from Hibiscus rosa-sinensis Linn.

Abstract

The air-dried flowers of Hibiscus rosa-sinensis Linn., commonly known as gumamela afforded 5,7,4′-trihydroxyflavanone (1), also known as naringenin, and a mixture of hydrocarbons and squalene. The structure of 1 was elucidated by extensive 1D and 2D NMR analyses. Antimicrobial tests on 1 indicated low activity against the bacterium, S. aureus and fungi, C. albicans and T. mentagrophytes. Compound 1 did not exhibit cytotoxicity against a human lung non-small cell adenocarcinoma (A549) cell line and a normal Chinese hamster ovarian (AA8) cell line. Read More

snip20161017_19

Antimicrobial Coumarin Derivative from Delonix regia

Abstract

The dichloromethane extract of the air-dried leaves of Delonix regia afforded scopoletin (1) by silica gel chromatography. The structure of 1 was determined by spectroscopic methods and confirmed by comparison of its 1H NMR data with those reported in the literature for scopoletin. Compound 1 exhibited antifungal activity against Candida albicans and antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Bubtilis subtilis. It was inactive against the fungi, Aspergillus niger and Trichophyton mentagrophytes.
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